http://www.skinfitnessfacts.com/news/2008/the-side-effects-from-too-much-vitamin-d/ Hydration, protection, and nutrition Tue, 06 Jan 2009 08:45:28 +0000 http://wordpress.org/?v=2.7 hourly 1 http://www.skinfitnessfacts.com/news/2008/the-side-effects-from-too-much-vitamin-d/comment-page-1/#comment-265 Ted Hutchinson Thu, 31 Jul 2008 18:14:21 +0000 http://www.skinfitnessfacts.com/news/?p=108#comment-265 Use of vitamin D in clinical practice. http://www.ncbi.nlm.nih.gov/pubmed/18377099 This paper explains why it is probably necessary to take more than 2000iu/daily/d3. In fact the suggested safe upper limit is 10,000iu/daily and that leaves a huge safety margin as 40,000iu/daily is needed daily over many months before 25(OH)D status is raised sufficiently to cause adverse events. each 100iu of D3 daily will raise status 1ng or 2.5nmol/l so 600iu will produce a 6ng 15nmol/l rise. You will see the average UK adult status is 50nml/l and so 600iu will only make that 65nmol/l and as 80nmol/l is required to maximise calcium uptake they would remain vitamin D deficient. Use of vitamin D in clinical practice.
http://www.ncbi.nlm.nih.gov/pubmed/18377099
This paper explains why it is probably necessary to take more than 2000iu/daily/d3.
In fact the suggested safe upper limit is 10,000iu/daily and that leaves a huge safety margin as 40,000iu/daily is needed daily over many months before 25(OH)D status is raised sufficiently to cause adverse events.
each 100iu of D3 daily will raise status 1ng or 2.5nmol/l
so 600iu will produce a 6ng 15nmol/l rise.
You will see the average UK adult status is 50nml/l and so 600iu will only make that 65nmol/l and as 80nmol/l is required to maximise calcium uptake they would remain vitamin D deficient.

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